Lynne Chou O’Keefe, MBA

Founder and Managing Partner, Define Ventures


Lynne Chou O’Keefe is founder and managing partner at Define Ventures, an early-stage fund focused on digital health solutions. She partners with entrepreneurs who are defining health care for the future. Most recently, she was a partner at Kleiner Perkins Caufield and Byers, where she focused on digital health and connected devices. She worked alongside entrepreneurs to develop technologies and therapies to improve patients’ lives. Her experience includes health care operating and investing roles.

Previously, O’Keefe worked at Abbott Vascular and Guidant in multiple roles, launching more than 10 interventional cardiology and cardiac surgery product families both in the US and internationally. Earlier in her career, she worked at Apax Partners with a focus on software venture capital investing. In addition, O’Keefe worked at Goldman Sachs in the Mergers and Acquisitions group. She was appointed to the CHCF board of directors in 2018.

O’Keefe holds a BS in industrial engineering from Stanford University and an MBA from Harvard Business School.